Genetic variation in susceptibility to endocrine disruption by estrogen in mice

被引：203

作者：

Spearow, JL ^{[1
]}

Doemeny, P ^{[1
]}

Sera, R ^{[1
]}

Leffler, R ^{[1
]}

Barkley, M ^{[1
]}

机构：

[1] Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA

来源：

SCIENCE | 1999年 / 285卷 / 5431期

关键词：

D O I：

10.1126/science.285.5431.1259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large (more than 16-fold) differences in susceptibility to disruption of juvenile male reproductive development by 17 beta-estradiol (E-2) were detected between strains of mice. Effects of strain, E-2 dose, and the interaction of strain and E-2 dose on testes weight and spermatogenesis were all highly significant (P < 0.0001). Spermatid maturation was eliminated by low doses of E-2 in strains such as C57BL/6J and C17/Jls. In contrast, mice of the widely used CD-1 line, which has been selected for large litter size, showed Little or no inhibition of spermatid maturation even in response to 16 times as much E-2. Product safety bioassays conducted with animals selected for fecundity may greatly underestimate disruption of male reproductive development by estradiol and environmental estrogenic compounds.

引用

页码：1259 / 1261

页数：3

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