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Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo

被引：36
作者：
Roach, DR
Briscoe, H
Baumgart, K
Rathjen, DA
Britton, WJ
机构：
[1] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia
[2] Univ Sydney, Dept Med, Sydney, NSW 2006, Australia
[3] Peptide Technol Ltd, Adelaide, SA, Australia
[4] Womens & Childrens Hosp, Dept Clin Immunol, Adelaide, SA, Australia
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 10期
关键词：
D O I：
10.1128/IAI.67.10.5473-5476.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF70-80) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.
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页码：5473 / 5476
页数：4
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