Cell cycle - Dual control of mitotic exit

被引:11
作者
Prinz, S [1 ]
Amon, A [1 ]
机构
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
关键词
D O I
10.1038/45949
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cell cycle consists of four phases: S phase (in which genetic material is duplicated); mitosis (during which it is segregated between two daughter cells); and two 'rest' phases, G1 and G2. The transition between mitosis and G1 needs to be precisely timed, and one of the molecular steps involved in controlling this transition has now been pinned down to a protein known as Cdc20.
引用
收藏
页码:133 / +
页数:2
相关论文
共 9 条
[1]   An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast [J].
Ciosk, R ;
Zachariae, W ;
Michaelis, C ;
Shevchenko, A ;
Mann, M ;
Nasmyth, K .
CELL, 1998, 93 (06) :1067-1076
[2]   Regulation of the APC and the exit from mitosis [J].
Morgan, DO .
NATURE CELL BIOLOGY, 1999, 1 (02) :E47-E53
[3]   Control of the yeast cell cycle by the Cdc28 protein kinase [J].
Nasmyth, Kim .
CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (02) :166-179
[4]   SCF and APC: the Yin and Yang of cell cycle regulated proteolysis [J].
Peters, JM .
CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (06) :759-768
[5]   The polo-like kinase Cdc5p and the WD-repeat protein Cdc2Op/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae [J].
Shirayama, M ;
Zachariae, W ;
Ciosk, R ;
Nasmyth, K .
EMBO JOURNAL, 1998, 17 (05) :1336-1349
[6]   APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5 [J].
Shirayama, M ;
Tóth, A ;
Gálová, M ;
Nasmyth, K .
NATURE, 1999, 402 (6758) :203-207
[7]   Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage [J].
Tinker-Kulberg, RL ;
Morgan, DO .
GENES & DEVELOPMENT, 1999, 13 (15) :1936-1949
[8]   Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s) [J].
Yamamoto, A ;
Guacci, V ;
Koshland, D .
JOURNAL OF CELL BIOLOGY, 1996, 133 (01) :99-110
[9]   Whose end is destruction: cell division and the anaphase-promoting complex [J].
Zachariae, W ;
Nasmyth, K .
GENES & DEVELOPMENT, 1999, 13 (16) :2039-2058