Evolution of short sequence repeats in Mycobacterium tuberculosis

被引:17
作者
Arnold, C [1 ]
Thorne, N [1 ]
Underwood, A [1 ]
Baster, K [1 ]
Gharbia, S [1 ]
机构
[1] Hlth Protect Agcy, Ctr Infect, London NW9 5HT, England
关键词
VNTR; MIRU; tuberculosis; molecular evolution;
D O I
10.1111/j.1574-6968.2006.00142.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Whole genome comparison has revealed the presence of short sequence repeats (also called mycobacterial interspersed repeat units and variable number tandem repeat units) used for genotyping schemes. In this study, we have used deletion analysis, single nucleotide polymorphism data and spoligotype taken from published data from others to investigate the evolution of selected repeats that form the common denominators of the majority of established schemes. Analysis of the number of repeats per locus from over 400 isolates revealed that the general trend globally appears to be loss of repeats in modern strains compared with ancestral strains.
引用
收藏
页码:340 / 346
页数:7
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