Solid-phase synthesis of cyclic imides

被引：17

作者：

Barn, DR ^{[1
]}

Morphy, JR ^{[1
]}

机构：

[1] Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1021/cc980024q

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A cyclative cleavage strategy for the synthesis of cyclic imides on a polystyrene resin is described. After optimization of the cleavage conditions, a small array of succinimides and phthalimides was synthesized. The methodology was then applied to a drug discovery project, in which it was used to synthesize a new class of delta-opioid receptor ligand by both automated and manual methods.

引用

页码：151 / 156

页数：6

共 8 条

[1] SYNTHESES OF N-SUBSTITUTED ISOINDOLINES .2. DERIVATIVES OF QUINOLINIMIDE
BARNES, RA
GODFREY, JC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1957, 22 (09) : 1043 - 1045
[2] DEWITT S, 1993, P NATL ACAD SCI USA, V90, P6911
[3] REDUCTIVE ALKYLATION ON A SOLID-PHASE - SYNTHESIS OF A PIPERAZINEDIONE COMBINATORIAL LIBRARY
GORDON, DW
STEELE, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (01) : 47 - 50
[4] HALL IH, 1990, BIOMED BIOCHIM ACTA, V49, P103
[5] Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones
Kolodziej, SA
Hamper, BC
[J]. TETRAHEDRON LETTERS, 1996, 37 (30) : 5277 - 5280
[6] PEPTIDE-SYNTHESIS - SYNTHESIS OF THE CYSTEINE-CONTAINING PEPTIDES OF BIOLOGICAL AND PHARMACEUTICAL INTEREST, ALPHA-H-ANF AND H-BIG ENDOTHELIN
RAMAGE, R
STEWART, ASJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (17): : 1947 - 1952
[7] Tietze LF, 1996, SYNLETT, P667
[8] BETA-PHENACYL ESTER AS A TEMPORARY PROTECTING GROUP TO MINIMIZE CYCLIC IMIDE FORMATION DURING SUBSEQUENT TREATMENT OF ASPARTYL PEPTIDES WITH HF
YANG, CC
MERRIFIELD, RB
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (06) : 1032 - 1041

← 1 →