The future of pediatric acute kidney injury management - Biomarkers

被引：20

作者：

Devarajan, Prasad ^{[1
,2
]}

机构：

[1] Univ Cincinnati, Med Ctr, Cincinnati Childrens Hosp, Dept Pediat, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Med Ctr, Cincinnati Childrens Hosp, Dept Dev Biol, Cincinnati, OH 45267 USA

来源：

SEMINARS IN NEPHROLOGY | 2008年 / 28卷 / 05期

关键词：

acute kidney injury; acute renal failure; biomarker; interleukin-18; kidney injury molecule-1; nephrotoxicity; neutrophil gelatinase-associated lipocalin; personalized medicine;

D O I：

10.1016/j.semnephrol.2008.05.010

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) represents a common and devastating problem in clinical medicine. A major reason is the lack of early biomarkers for AKI, and hence an unacceptable delay in initiating therapy. Fortunately, the application of innovative technologies has uncovered several novel biomarkers. The most promising of these are included in a putative AKI biomarker panel, consisting of neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1. These biomarkers have completed initial validation, and have entered the prospective screening stage in the biomarker development process, facilitated by the development of commercial tools for their reproducible measurement across laboratories. The availability of a panel of validated biomarkers will revolutionize renal and critical care, and enable the practice of personalized and predictive medicine at,in unprecedented level.

引用

页码：493 / 498

页数：6

共 37 条

[1] Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study
Bennett, Michael
Dent, Catherine L.
Ma, Qing
Dastrala, Sudha
Grenier, Frank
Workman, Ryan
Syed, Hina
Ali, Salman
Barasch, Jonathan
Devarajan, Prasad
[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (03): : 665 - 673
[2] Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
Chertow, GM
Burdick, E
Honour, M
Bonventre, JV
Bates, DW
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (11): : 3365 - 3370
[3] Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
Dent, Catherine L.
Ma, Qing
Dastrala, Sudha
Bennett, Michael
Mitsnefes, Mark M.
Barasch, Jonathan
Devarajan, Prasad
[J]. CRITICAL CARE, 2007, 11 (06):
[4] Devarajan Prasad, 2007, Cancer Ther, V5, P463
[5] Devarajan P, 2008, NEW ENGL J MED, V358, P312
[6] Devarajan P, 2007, CONTRIB NEPHROL, V156, P203
[7] Update on mechanisms of ischemic acute kidney injury
Devarajan, Prasad
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (06): : 1503 - 1520
[8] Proteomics for biomarker discovery in acute kidney injury
Devarajan, Prosad
[J]. SEMINARS IN NEPHROLOGY, 2007, 27 (06) : 637 - 651
[9] Kidney function assessment in the critically ill child: is it time to leave creatinine behind?
Goldstein, Stuart L.
[J]. CRITICAL CARE, 2007, 11 (03):
[10] Urinary biomarkers in the early diagnosis of acute kidney injury
Han, W. K.
Waikar, S. S.
Johnson, A.
Betensky, R. A.
Dent, C. L.
Devarajan, P.
Bonventre, J. V.
[J]. KIDNEY INTERNATIONAL, 2008, 73 (07) : 863 - 869

← 1 2 3 4 →