The seventh myth of lipoprotein(a): where and how is it assembled?

被引：37

作者：

Dieplinger, H ^{[1
]}

Utermann, G ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Med Biol & Human Genet, A-6020 Innsbruck, Austria

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1097/00041433-199906000-00010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of the genetics, metabolism and pathophysiology of the atherogenic plasma lipoprotein Lp(a) has considerably increased over past years. Nevertheless, the precise mechanisms regulating the biosynthesis and assembly of Lp(a) are poorly understood and controversially discussed. Lp(a) plasma concentrations are determined by synthesis and not by degradation. Transcriptional and post-translational mechanisms have been identified as regulating Lp(a) production in primary hepatocytes and transfected cell lines. Assembly of Lp(a) occurs extracellularly from newly synthesized apolipoprotein(a) and circulating LDL. This view has recently been challenged by in-vivo kinetic studies in humans which are compatible with an intracellular assembly event. Lp(a) assembly is a complex two-step process of multiple non-covalent interactions between apolipoprotein(a) and apolipoprotein B-100 of LDL followed by covalent disulfide linkage of two free cysteine residues on both proteins. Curr Opin Lipidol 10:275-283. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：275 / 283

页数：9

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