Introns and the origin of nucleus-cytosol compartmentalization

被引：369

作者：

Martin, W ^{[1
]}

Koonin, EV

机构：

[1] Univ Dusseldorf, Inst Bot 3, D-40225 Dusseldorf, Germany

[2] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

来源：

NATURE | 2006年 / 440卷 / 7080期

关键词：

D O I：

10.1038/nature04531

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to go to completion so that translation, which is fast, would occur only on mRNA with intact reading frames. The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus - cytosol compartmentalization.

引用

页码：41 / 45

页数：5

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