Emerging pathways in colorectal-cancer development

被引：116

作者：

Haydon, AMM ^{[1
]}

Jass, JR ^{[1
]}

机构：

[1] Univ Queensland, Mayne Med Sch, Dept Pathol, Herston, Qld, Australia

来源：

LANCET ONCOLOGY | 2002年 / 3卷 / 02期

关键词：

D O I：

10.1016/S1470-2045(02)00649-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The past decade has seen the emergence of new pathways in the development of colorectal cancer. There is now clear evidence that subsets of these tumours do not show chromosomal instability and do not follow the suppressor pathway. Instead, about 15% of colorectal cancers are characterised by microsatellite instability (MSI). This feature arises through defective DNA mismatch repair, which is related either to a germline mutation (as in hereditary non-polyposis colorectal carcinoma) or to failure to express a mismatch-repair gene. CpG-island methylation has been linked to sporadic cancers with a high frequency of MSI. This type of methylation leads to loss of gene expression when it occurs in the promoter region of a gene. Tumours may have high or low type C (cancer-related) CpG-island methylation. When methylation affects hMLH1 (mismatch repair gene), the resultant cancer has high MSI.

引用

页码：83 / 88

页数：6

共 64 条

[31]

KIM GP, 2001, P AN M AM SOC CLIN, V20, P1666

[32]

KIM HG, 1994, AM J PATHOL, V145, P148

[33] Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer [J].

Konishi, M ;

KikuchiYanoshita, R ;

Tanaka, K ;

Muraoka, M ;

Onda, A ;

Okumura, Y ;

Kishi, N ;

Iwama, T ;

Mori, T ;

Koike, M ;

Ushio, K ;

Chiba, M ;

Nomizu, S ;

Konishi, F ;

Utsunomiya, J ;

Miyaki, M .

GASTROENTEROLOGY, 1996, 111 (02) :307-317

[34] Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers [J].

Kuismanen, SA ;

Holmberg, MT ;

Salovaara, R ;

de la Chapelle, A ;

Peltomäki, P .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (05) :1773-1779

[35] Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers [J].

Kuismanen, SA ;

Holmberg, MT ;

Salovaara, R ;

Schweizer, P ;

Aaltonen, LA ;

de la Chapelle, A ;

Nyström-Lahti, M ;

Peltomäki, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12661-12666

[36] APC mutations are sufficient for the growth of early colorectal adenomas [J].

Lamlum, H ;

Papadopoulou, A ;

Ilyas, M ;

Rowan, A ;

Gillet, C ;

Hanby, A ;

Talbot, I ;

Bodmer, W ;

Tomlinson, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) :2225-2228

[37] MISMATCH REPAIR GENE DEFECTS IN SPORADIC COLORECTAL CANCERS WITH MICROSATELLITE INSTABILITY [J].

LIU, B ;

NICOLAIDES, NC ;

MARKOWITZ, S ;

WILLSON, JKV ;

PARSONS, RE ;

JEN, J ;

PAPADOPOLOUS, N ;

PELTOMAKI, P ;

DELACHAPELLE, A ;

HAMILTON, SR ;

KINZLER, KW ;

VOGELSTEIN, B .

NATURE GENETICS, 1995, 9 (01) :48-55

[38] Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients [J].

Liu, B ;

Parsons, R ;

Papadopoulos, N ;

Nicolaides, NC ;

Lynch, HT ;

Watson, P ;

Jass, JR ;

Dunlop, M ;

Wyllie, A ;

Peltomaki, P ;

delaChapelle, A ;

Hamilton, SR ;

Vogelstein, B ;

Kinzler, KW .

NATURE MEDICINE, 1996, 2 (02) :169-174

[39]

Losi L, 1997, INT J CANCER, V74, P94, DOI 10.1002/(SICI)1097-0215(19970220)74:1<94::AID-IJC16>3.0.CO

[40]

2-I

← 1 2 3 4 5 6 7 →