Stereoselective syntheses of beta-L-FD4C and beta-L-FddC

被引:16
作者
Chen, SH
Li, XY
Li, J
Niu, CS
Carmichael, E
Doyle, TW
机构
[1] Vion Pharmaceuticals, Inc., New Haven, CT 06511
关键词
D O I
10.1021/jo970177k
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Stereocontrolled syntheses of two potent antiviral agents, beta-L-FD4C and beta-L-FddC, were accomplished both in 10-step sequences, with an overall yield of 27% and 25%, respectively. It is worthwhile to mention that the introduction of a phenylseleno moiety to the C-2 alpha position of the lactone 4 can now be performed in a stereocontrolled fashion, providing the key intermediate 5 alpha in 75% yield.
引用
收藏
页码:3449 / 3452
页数:4
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