Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders

被引：177

作者：

Kovács, T ^{[1
]}

机构：

[1] Semmelweis Univ, Sch Med, Dept Neurol, H-1083 Budapest, Hungary

来源：

AGEING RESEARCH REVIEWS | 2004年 / 3卷 / 02期

基金：

英国惠康基金;

关键词：

olfaction; aging; Alzheimer's disease; Parkinson's disease; Parkinsonian syndromes; Creutzfeldt-Jakob disease;

D O I：

10.1016/j.arr.2003.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although olfaction is the primal sense in animals, its importance in humans is underappreciated. Extensive literature demonstrates that aging is accompanied by olfactory loss and hyposmia/anosmia which is also a feature of several neurodegenerative disorders. Alzheimer's and Parkinson's diseases are characterized by severe olfactory deficits, while problems of olfactory discrimination are less prominent features in several other disorders. Olfactory loss is accompanied by structural abnormalities of the olfactory epithelium, the olfactory bulb and the central olfactory cortices. This review summarizes our present knowledge about the pathological changes in the olfactory system during aging and in various neurodegenerative diseases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：215 / 232

页数：18

共 77 条

[1] OLFACTORY FUNCTION IN PATIENTS WITH PARKINSONS-DISEASE [J].

ANSARI, KA ;

JOHNSON, A .

JOURNAL OF CHRONIC DISEASES, 1975, 28 (09) :493-497

[2] NUMBER OF MITRAL CELLS AND THE BULB VOLUME IN THE AGING HUMAN OLFACTORY-BULB - A QUANTITATIVE MORPHOLOGICAL-STUDY [J].

BHATNAGAR, KP ;

KENNEDY, RC ;

BARON, G ;

GREENBERG, RA .

ANATOMICAL RECORD, 1987, 218 (01) :73-87

[3] Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen [J].

Braak, H ;

Rüb, U ;

Gai, WP ;

Del Tredici, K .

JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (05) :517-536

[4] AMYGDALA PATHOLOGY IN PARKINSONS-DISEASE [J].

BRAAK, H ;

BRAAK, E ;

YILMAZER, D ;

DEVOS, RAI ;

JANSEN, ENH ;

BOHL, J ;

JELLINGER, K .

ACTA NEUROPATHOLOGICA, 1994, 88 (06) :493-500

[5] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[6] PATTERNS OF ADRENERGIC AND PEPTIDERGIC INNERVATION IN HUMAN OLFACTORY MUCOSA - AGE-RELATED TRENDS [J].

CHEN, Y ;

GETCHELL, TV ;

SPARKS, DL ;

GETCHELL, ML .

JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 334 (01) :104-116

[7] PRELIMINARY DIAGNOSIS OF PARKINSONS-DISEASE BY OLFACTORY-BULB PATHOLOGY [J].

DANIEL, SE ;

HAWKES, CH .

LANCET, 1992, 340 (8812) :186-186

[8]

DeArmond SJ, 2002, Greenfield's neuropathology, V7th, P273

[9] PRESENCE OF BOTH ODOR IDENTIFICATION AND DETECTION DEFICITS IN ALZHEIMERS-DISEASE [J].

DOTY, RL ;

REYES, PF ;

GREGOR, T .

BRAIN RESEARCH BULLETIN, 1987, 18 (05) :597-600

[10] LACK OF MAJOR OLFACTORY DYSFUNCTION IN MPTP-INDUCED PARKINSONISM [J].

DOTY, RL ;

SINGH, A ;

TETRUD, J ;

LANGSTON, JW .

ANNALS OF NEUROLOGY, 1992, 32 (01) :97-100

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