Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders

被引：177

作者：

Kovács, T ^{[1
]}

机构：

[1] Semmelweis Univ, Sch Med, Dept Neurol, H-1083 Budapest, Hungary

来源：

AGEING RESEARCH REVIEWS | 2004年 / 3卷 / 02期

基金：

英国惠康基金;

关键词：

olfaction; aging; Alzheimer's disease; Parkinson's disease; Parkinsonian syndromes; Creutzfeldt-Jakob disease;

D O I：

10.1016/j.arr.2003.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although olfaction is the primal sense in animals, its importance in humans is underappreciated. Extensive literature demonstrates that aging is accompanied by olfactory loss and hyposmia/anosmia which is also a feature of several neurodegenerative disorders. Alzheimer's and Parkinson's diseases are characterized by severe olfactory deficits, while problems of olfactory discrimination are less prominent features in several other disorders. Olfactory loss is accompanied by structural abnormalities of the olfactory epithelium, the olfactory bulb and the central olfactory cortices. This review summarizes our present knowledge about the pathological changes in the olfactory system during aging and in various neurodegenerative diseases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：215 / 232

页数：18

共 77 条

[71]

VESTERVELT HJ, 2003, COGN BEHAV NEUROL, V16, P93

[72] OLFACTORY FUNCTION IN ATYPICAL PARKINSONIAN SYNDROMES [J].

WENNING, GK ;

SHEPHARD, B ;

HAWKES, C ;

PETRUCKEVITCH, A ;

LEES, A ;

QUINN, N .

ACTA NEUROLOGICA SCANDINAVICA, 1995, 91 (04) :247-250

[73] Some neuropathological aspects of Alzheimer's disease and its relevance to other disciplines [J].

Wisniewski, HM ;

Wegiel, J ;

Kotula, L .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1996, 22 (01) :3-11

[74] Ontogenetic expression of spot 35 protein (calbindin-D28k) in human olfactory receptor neurons and its decrease in Alzheimer's disease patients [J].

Yamagishi, M ;

Takami, S ;

Getchell, TV .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1996, 105 (02) :132-139

[75]

YOSHIMURA N, 1988, ACTA NEUROPATHOL, V77, P202

[76] Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease [J].

Zanusso, G ;

Ferrari, S ;

Cardone, F ;

Zampieri, P ;

Gelati, M ;

Fiorini, M ;

Farinazzo, A ;

Gardiman, M ;

Cavallaro, T ;

Bentivoglio, M ;

Righetti, PG ;

Pocchiari, M ;

Rizzuto, N ;

Monaco, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (08) :711-719

[77] FUNCTIONAL LOCALIZATION AND LATERALIZATION OF HUMAN OLFACTORY CORTEX [J].

ZATORRE, RJ ;

JONESGOTMAN, M ;

EVANS, AC ;

MEYER, E .

NATURE, 1992, 360 (6402) :339-340

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