Cross-reactive antibodies prevent the lethal effects of Staphylococcus aureus superantigens

被引:41
作者
Bavari, S [1 ]
Ulrich, RG [1 ]
LeClaire, RD [1 ]
机构
[1] USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Frederick, MD 21702 USA
来源
JOURNAL OF INFECTIOUS DISEASES | 1999年 / 180卷 / 04期
关键词
D O I
10.1086/314977
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The exotoxins produced by Staphylococcus aureus, staphylococcal enterotoxins (SE) A-E and toxic shock syndrome toxin (TSST)-1, which are associated with serious diseases, including food poisoning and toxic shock syndrome, are termed superantigens (SAgs), To examine whether common antigenic epitopes were present and whether vaccination with 1 bacterial SAg could protect against challenge with a different SE or TSST-1, mice were vaccinated with SEA, SEE, SEC1, or TSST-1 individually or in combination. Mice injected with a single toxin developed high antibody titers against other SAgs, Marked improvement in survival was observed when immunized mice were challenged with a heterologous toxin, Mice vaccinated with a mixture of toxins were fully protected against 1 or multiple toxin challenges, indicating no interference effects of multivalent vaccinations, More importantly, higher titers were found against each SAg with the multivalent vaccination than with injection with a single SAg, Thus, immunizations with 1 SAg can induce cross-protective antibodies to heterologous SAgs, and multicomponent vaccination can enhance antibody responses against each bacterial SAg.
引用
收藏
页码:1365 / 1369
页数:5
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