Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa

被引：53

作者：

Park, Junguk ^{[2
,3
]}

Kaufmann, Gunnar F. ^{[2
,3
]}

Bowen, J. Phillip ^{[4
]}

Arbiser, Jack L. ^{[5
]}

Janda, Kim D. ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Worm Inst Res & Med, Dept Chem & Immunol, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA USA

[3] Skaggs Inst Chem Biol, Dept Immunol, La Jolla, CA USA

[4] Univ N Carolina, Ctr Drug Discovery, Dept Chem & Biochem, Greensboro, NC 27412 USA

[5] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1086/591916

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Pseudomonas aeruginosa, quorum-sensing (QS) signaling regulates the expression of virulence factors and thus represents an attractive new target for anti-infective therapy. In the present study, we investigated whether solenopsin A, a venom alkaloid from the fire ant, possessed agonistic or antagonistic QS signaling activity in P. aeruginosa. We evaluated the modulation of virulence factor expression and transcriptional levels of QS-regulated genes in P. aeruginosa by solenopsin A and demonstrated that solenopsin A efficiently disrupted QS signaling. Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, restored P. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL- dependent rhl QS system.

引用

页码：1198 / 1201

页数：4

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