Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

被引：298

作者：

Lau, GW

Ran, HM

Kong, FS

Hassett, DJ

Mavrodi, D

机构：

[1] Univ Cincinnati, Coll Med, Div Pulm & Crit Care Med, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA

[3] Washington State Univ, Dept Plant Pathol, Agr Res Serv, Pullman, WA 99164 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 07期

关键词：

D O I：

10.1128/IAI.72.7.4275-4278.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

引用

收藏

页码：4275 / 4278

页数：4

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