Molecular basis of the interaction of Salmonella with the intestinal mucosa

被引:300
作者
Darwin, KH
Miller, VL
机构
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
关键词
D O I
10.1128/CMR.12.3.405
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Salmonella is one of the most extensively characterized bacterial pathogens and is a leaning cause of bacterial gastroenteritis. Despite this, we are only just beginning to understand at a molecular level how Salmonella interacts with its mammalian hosts to cause disease. Studies during the past decade on the genetic basis of virulence of Salmonella have significantly advanced our understanding of the molecular basis of the host-pathogen interaction, yet many questions remain. In this review, we focus on the interaction of enterocolitis-causing salmonella with the intestinal mucosa, since this is the initiating step for most infections caused by Salmonella. Animal and in vitro cell culture models for the interaction of these bacteria with the intestinal epithelium are reviewed, along with the bacterial genes that am thought to affect this interaction Lastly, recent studies on the response of epithelial cells to Salmonella infection and how this might promote diarrhea are discussed.
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页码:405 / +
页数:25
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