Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera

被引：118

作者：

Zhang, XF

Wang, HM

Song, YL

Nie, LH

Wang, LF

Liu, B

Shen, PP

Liu, Y ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci, Beijing 100080, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut & Biotechnol, Nanjing 210008, Peoples R China

[3] Hunan Univ, State Key Lab Chem Biosensing & Chemomet, Changsha 510008, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

aloe; dihydrocoumarins; X-ray crystallography; NMR; antioxidant; immunomodulatory activity;

D O I：

10.1016/j.bmcl.2005.10.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently sit owed antioxidant activity against superoxide and hydroxyl radicals. Only I obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：949 / 953

页数：5

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