Nonpeptidic foldamers from amino acids: Synthesis and characterization of 1,3-substituted triazole oligomers

被引:187
作者
Angelo, NG [1 ]
Arora, PS [1 ]
机构
[1] NYU, Dept Chem, New York, NY 10003 USA
关键词
D O I
10.1021/ja056406z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the β-strand structure, predominates in two different tetramers. Copyright © 2005 American Chemical Society.
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页码:17134 / 17135
页数:2
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