Perturbation of nucleotide metabolism - the driving force of oncogene-induced senescence

被引:5
作者
Darzynkiewicz, Zbigniew [1 ,2 ]
机构
[1] New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
[2] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA
关键词
DNA-DAMAGE;
D O I
10.18632/oncotarget.1023
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
[No abstract available]
引用
收藏
页码:649 / 650
页数:2
相关论文
共 8 条
[1]
Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence [J].
Aird, Katherine M. ;
Zhang, Gao ;
Li, Hua ;
Tu, Zhigang ;
Bitler, Benjamin G. ;
Garipov, Azat ;
Wu, Hong ;
Wei, Zhi ;
Wagner, Stephan N. ;
Herlyn, Meenhard ;
Zhang, Rugang .
CELL REPORTS, 2013, 3 (04) :1252-1265
[2]
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development [J].
Bester, Assaf C. ;
Roniger, Maayan ;
Oren, Yifat S. ;
Im, Michael M. ;
Sarni, Dan ;
Chaoat, Malka ;
Bensimon, Aaron ;
Zamir, Gideon ;
Shewach, Donna S. ;
Kerem, Batsheva .
CELL, 2011, 145 (03) :435-446
[3]
The essence of senescence [J].
Kuilman, Thomas ;
Michaloglou, Chrysiis ;
Mooi, Wolter J. ;
Peeper, Daniel S. .
GENES & DEVELOPMENT, 2010, 24 (22) :2463-2479
[4]
Global Regulation of Nucleotide Biosynthetic Genes by c-Myc [J].
Liu, Yen-Chun ;
Li, Feng ;
Handler, Jesse ;
Huang, Cheng Ran Lisa ;
Xiang, Yan ;
Neretti, Nicola ;
Sedivy, John M. ;
Zeller, Karen I. ;
Dang, Chi V. .
PLOS ONE, 2008, 3 (07)
[5]
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells [J].
Mannava, Sudha ;
Grachtchouk, Vladimir ;
Wheeler, Linda J. ;
Im, Michael ;
Zhuang, Dazhong ;
Slavina, Elena G. ;
Mathews, Christopher K. ;
Shewach, Donna S. ;
Nikiforov, Mikhail A. .
CELL CYCLE, 2008, 7 (15) :2392-2400
[6]
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion [J].
Mannava, Sudha ;
Moparthy, Kalyana C. ;
Wheeler, Linda J. ;
Leonova, Katerina I. ;
Wawrzyniak, Joseph A. ;
Bianchi-Smiraglia, Anna ;
Berman, Albert E. ;
Flanagan, Sheryl ;
Shewach, Donna S. ;
Zeitouni, Nathalie C. ;
Gudkov, Andrei V. ;
Mathews, Christopher K. ;
Nikiforov, Mikhail A. .
AGING-US, 2012, 4 (12) :917-922
[7]
Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence [J].
Mannava, Sudha ;
Moparthy, Kalyana C. ;
Wheeler, Linda J. ;
Natarajan, Venkatesh ;
Zucker, Shoshanna N. ;
Fink, Emily E. ;
Im, Michael ;
Flanagan, Sheryl ;
Burhans, William C. ;
Zeitouni, Nathalie C. ;
Shewach, Donna S. ;
Mathews, Christopher K. ;
Nikiforov, Mikhail A. .
AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (01) :142-151
[8]
Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence [J].
McKenna, Elise ;
Traganos, Frank ;
Zhao, Hong ;
Darzynkiewicz, Zbigniew .
CELL CYCLE, 2012, 11 (16) :3132-3140