The essence of senescence

被引：1614

作者：

Kuilman, Thomas ^{[1
]}

Michaloglou, Chrysiis ^{[1
]}

Mooi, Wolter J. ^{[2
]}

Peeper, Daniel S. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 22期

关键词：

Telomeres; oncogenes; tumor suppressor genes; senescence; in vivo; biomarkers; ONCOGENE-INDUCED SENESCENCE; NORMAL HUMAN FIBROBLASTS; DNA-DAMAGE RESPONSE; CELL-CYCLE ARREST; MAMMARY EPITHELIAL-CELLS; REPLICATIVE LIFE-SPAN; DEMETHYLASE JMJD3 CONTRIBUTES; INDUCED PREMATURE SENESCENCE; BETA-GALACTOSIDASE ACTIVITY; HUMAN-DIPLOID FIBROBLASTS;

D O I：

10.1101/gad.1971610

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.

引用

收藏

页码：2463 / 2479

页数：17

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