Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

被引：252

作者：

Adams, Peter D. ^{[1
]}

机构：

[1] Univ Glasgow, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

来源：

MOLECULAR CELL | 2009年 / 36卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ONCOGENE-INDUCED SENESCENCE; DEMETHYLASE JMJD3 CONTRIBUTES; GENOME-WIDE ASSOCIATION; HUMAN ENDOTHELIAL-CELLS; DNA-DAMAGE; LIFE-SPAN; P38; MAPK; IN-VITRO; MATRIX METALLOPROTEINASES; REPLICATIVE SENESCENCE;

D O I：

10.1016/j.molcel.2009.09.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence is a proliferation arrest that is typically irreversible and caused by various cellular stresses, including excess rounds of cell division and cancer-causing genetic alterations. Senescence actively contributes to a tissue-level response to tissue wounding and incipient cancer, healing the tissue and suppressing tumor formation. However, in the long term, the same senescence program may hurt the tissue, thereby contributing to tissue aging. Tumor suppression, wound healing, and aging are each associated with inflammation, and here it is proposed that cellular senescence contributes to a "nonimmune cell" component of the tissue inflammatory response.

引用

页码：2 / 14

页数：13

共 130 条

[1] Chemokine signaling via the CXCR2 receptor reinforces senescence [J].

Acosta, Juan C. ;

O'Loghlen, Ana ;

Banito, Ana ;

Guijarro, Maria V. ;

Augert, Arnaud ;

Raguz, Selina ;

Fumagalli, Marzia ;

Da Costa, Marco ;

Brown, Celia ;

Popov, Nikolay ;

Takatsu, Yoshihiro ;

Melamed, Jonathan ;

di Fagagna, Fabrizio d'Adda ;

Bernard, David ;

Hernando, Eva ;

Gil, Jesus .

CELL, 2008, 133 (06) :1006-1018

[2] Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging [J].

Adams, Peter D. .

GENE, 2007, 397 (1-2) :84-93

[3] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Rudkjaer, Lise ;

Williams, Kristine ;

Andersen, Gitte ;

Christensen, Jesper ;

Helin, Kristian .

GENES & DEVELOPMENT, 2009, 23 (10) :1171-1176

[4] Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency [J].

Baker, Darren J. ;

Perez-Terzic, Carmen ;

Jin, Fang ;

Pitel, Kevin ;

Niederlaender, Nicolas J. ;

Jeganathan, Karthik ;

Yamada, Satsuki ;

Reyes, Santiago ;

Rowe, Lois ;

Hiddinga, H. Jay ;

Eberhardt, Norman L. ;

Terzic, Andre ;

van Deursen, Jan M. .

NATURE CELL BIOLOGY, 2008, 10 (07) :825-836

[5] Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells [J].

Banumathy, Gowrishankar ;

Somaiah, Neeta ;

Zhang, Rugang ;

Tang, Yong ;

Hoffmann, Jason ;

Andrake, Mark ;

Ceulemans, Hugo ;

Schultz, David ;

Marmorstein, Ronen ;

Adams, Peter D. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (03) :758-770

[6]

Barnhill RL., 2004, Pathology of melanocytic nevi and malignant melanoma

[7] Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS [J].

Barradas, Marta ;

Anderton, Emma ;

Acosta, Juan Carlos ;

Li, SiDe ;

Banito, Ana ;

Rodriguez-Niedenfuehr, Marc ;

Maertens, Goedele ;

Banck, Michaela ;

Zhou, Ming-Ming ;

Walsh, Martin J. ;

Peters, Gordon ;

Gil, Jesus .

GENES & DEVELOPMENT, 2009, 23 (10) :1177-1182

[8] Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints [J].

Bartkova, Jirina ;

Rezaei, Nousin ;

Liontos, Michalis ;

Karakaidos, Panagiotis ;

Kletsas, Dimitris ;

Issaeva, Natalia ;

Vassiliou, Leandros-Vassilios F. ;

Kolettas, Evangelos ;

Niforou, Katerina ;

Zoumpourlis, Vassilis C. ;

Takaoka, Munenori ;

Nakagawa, Hiroshi ;

Tort, Frederic ;

Fugger, Kasper ;

Johansson, Fredrik ;

Sehested, Maxwell ;

Andersen, Claus L. ;

Dyrskjot, Lars ;

Orntoft, Torben ;

Lukas, Jiri ;

Kittas, Christos ;

Helleday, Thomas ;

Halazonetis, Thanos D. ;

Bartek, Jiri ;

Gorgoulis, Vassilis G. .

NATURE, 2006, 444 (7119) :633-637

[9] NF-κB- and C/EBPβ-driven interleukin-1β gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1β release from Helicobacter pylori lipopolysaccharide-stimulated macrophages [J].

Basak, C ;

Pathak, SK ;

Bhattacharyya, A ;

Mandal, D ;

Pathak, S ;

Kundu, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4279-4288

[10] Reversal of human cellular senescence:: roles of the p53 and p16 pathways [J].

Beauséjour, CM ;

Krtolica, A ;

Galimi, F ;

Narita, M ;

Lowe, SW ;

Yaswen, P ;

Campisi, J .

EMBO JOURNAL, 2003, 22 (16) :4212-4222

← 1 2 3 4 5 6 7 8 9 10 →