Mass spectrometry of RNA

被引：47

作者：

Thomas, B ^{[1
]}

Akoulitchev, AV ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Cent Prote Facil, Oxford OX1 3RE, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 03期

关键词：

D O I：

10.1016/j.tibs.2006.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A complex population of non-coding RNAs is present in higher organisms. These RNAs have a multitude of functions and execute control over gene expression through various, often poorly understood, mechanisms. At present, the identification and analysis of functional regulatory RNAs and disparate ribonucleoprotein complexes remain an experimental challenge for biologists. They require specially designed approaches and techniques in genomics and RNA biochemistry. Developments in technologies based on mass spectrometry could offer sensitive and efficient solutions to analysis of the sequence, structure, modification and composition of RNA.

引用

页码：173 / 181

页数：9

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