Closed-Loop Control of Epilepsy by Transcranial Electrical Stimulation

被引：342

作者：

Berenyi, Antal ^{[1
,2
,3
]}

Belluscio, Mariano ^{[1
]}

Mao, Dun ^{[1
]}

Buzsaki, Gyoergy ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA

[2] NYU, Sch Med, Inst Neurosci, New York, NY 10016 USA

[3] Univ Szeged, Dept Physiol, H-6720 Szeged, Hungary

来源：

SCIENCE | 2012年 / 337卷 / 6095期

关键词：

DEEP BRAIN-STIMULATION; SLEEP; SPINDLES; MEMORY; SPIKE; RATS;

D O I：

10.1126/science.1223154

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.

引用

页码：735 / 737

页数：3

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