Separation of Nanoparticles in Aqueous Multiphase Systems through Centrifugation

被引：174

作者：

Akbulut, Ozge ^{[1
,2
]}

Mace, Charles R. ^{[1
,2
]}

Martinez, Ramses V. ^{[1
,2
]}

Kumar, Ashok A. ^{[3
]}

Nie, Zhihong ^{[1
,2
]}

Patton, Matthew R. ^{[1
,2
]}

Whitesides, George M. ^{[1
,2
,4
,5
]}

机构：

[1] Harvard Univ, Dept Chem, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Biol Chem, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Cambridge, MA 02138 USA

[5] Harvard Univ, Kavli Inst Bionano Sci & Technol, Cambridge, MA 02138 USA

来源：

NANO LETTERS | 2012年 / 12卷 / 08期

基金：

美国国家科学基金会;

关键词：

Centrifugation; nanoparticles; separation; polymers; multiphase systems; GOLD NANORODS; ASPECT-RATIO; SHAPE SEPARATION; SIZE; GRADIENT; PURIFICATION; ABSORPTION; PARTICLES; MECHANISM;

D O I：

10.1021/nl301452x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper demonstrates the use of aqueous multiphase systems (MuPSs) as media for rate-zonal centrifugation to separate nanoparticles of different shapes and sizes. The properties of MuPSs do not change with time or during centrifugation; this stability facilitates sample collection after separation. A three-phase system demonstrates the separation of the reaction products (nanorods, nanospheres, and large particles) of a synthesis of gold nanorods, and enriches the nanorods from 48 to 99% in less than ten minutes using a benchtop centrifuge.

引用

页码：4060 / 4064

页数：5

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