No effect of anti-leprosy drugs in the prevention of Alzheimer's disease and β-amyloid neurotoxicity

被引：30

作者：

Endoh, M ^{[1
]}

Kunishita, T

Tabira, T

机构：

[1] NCNP, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Tokyo 1878502, Japan

[2] Natl Inst Infect Dis, Leprosy Res Ctr, Dept Bioregulat, Tokyo 1890002, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1999年 / 165卷 / 01期

关键词：

anti-leprosy drug; dementia; amyloid beta-protein; neurotoxicity; Alzheimer's disease;

D O I：

10.1016/S0022-510X(99)00057-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is continuing controversy as to whether or not anti-leprosy drugs prevent Alzheimer's disease (AD). Therefore, we examined the effect of anti-leprosy drugs on the prevalence of AD in leprosy patients, and also investigated the effect of anti-leprosy drugs on amyloid beta-protein (A beta)-induced neurotoxicity in vitro. The present study suggests that anti-leprosy treatments do not prevent the onset of AD. None of our data found anti-leprosy drugs (dapsone, rifampicin, clofazimine, minomycin or ofloxacin) had any effect on A beta neurotoxicity. It is now important to examine the infection of Mycobacterium leprae in the central nervous system to clarify the reason for the low prevalence of senile dementia, and low frequency of A beta deposition in leprosy patients. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：28 / 30

页数：3

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