Significantly increased frequency of the apolipoprotein E epsilon 4 allele in elderly non-demented leprosy patients

被引：6

作者：

Endoh, M

Ueki, A

Takahashi, K

Yamanaka, H

Izumi, S

Tabira, T

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV DEMYELINATING DIS & AGING,KODAIRA,TOKYO 187,JAPAN

[2] NATL INST LEPROSY RES,DEPT BIOREGULAT,HIGASHIMURAYAMA,TOKYO 189,JAPAN

[3] OMIYA MED CTR,JICHI MED SCH,DEPT NEUROL,OMIYA,SAITAMA 330,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 207卷 / 03期

关键词：

leprosy; apolipoprotein E; Alzheimer's disease; dementia; 4,4'-diaminodiphenyl sulfone;

D O I：

10.1016/0304-3940(96)12513-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E (apo E) genotypes in 350 leprosy patients were examined and compared with those of 870 age-matched controls. The allelic frequencies of the apo E gene did not differ between demented patients with leprosy and controls. However, the frequency of apo E epsilon 4 allele was significantly higher in non-demented leprosy patients than in controls (P < 0.001). Of special interest is that the prevalence of E3/4 genotype in non-demented leprosy patients increased significantly with age, being 14.1%, 24.4%, and 28.3% in the 60s, 70s, and 80s, respectively (P < 0.05). These data suggest that apo E epsilon 4 is not a risk factor for senile dementia in elderly leprosy patients, and there exist factors to overcome the risk of apo E4 in leprosy patients.

引用

页码：206 / 208

页数：3

共 11 条

[1]

CHUI DH, 1994, AM J PATHOL, V145, P771

[2] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[3] NEUROPATHOLOGICAL ANALYSIS OF DEMENTIA IN A JAPANESE LEPROSARIUM [J].

GOTO, M ;

KIMURA, T ;

HAGIO, S ;

UEDA, K ;

KITAJIMA, SI ;

TOKUNAGA, H ;

SATO, E .

DEMENTIA, 1995, 6 (03) :157-161

[4] APOLIPOPROTEIN-E ALLELE EPSILON-4, DEMENTIA, AND COGNITIVE DECLINE IN A POPULATION-SAMPLE [J].

HENDERSON, AS ;

EASTEAL, S ;

JORM, AF ;

MACKINNON, AJ ;

KORTEN, AE ;

CHRISTENSEN, H ;

CROFT, L ;

JACOMB, PA .

LANCET, 1995, 346 (8987) :1387-1390

[5] PREVALENCE OF DEMENTIA AMONGST ELDERLY JAPANESE WITH LEPROSY - APPARENT EFFECT OF CHRONIC DRUG-THERAPY [J].

MCGEER, PL ;

HARADA, N ;

KIMURA, H ;

MCGEER, EG ;

SCHULZER, M .

DEMENTIA, 1992, 3 (03) :146-149

[6] NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN BRAIN OF ELDERLY LEPROSY PATIENTS [J].

NAMBA, Y ;

KAWATSU, K ;

IZUMI, S ;

UEKI, A ;

IKEDA, K .

LANCET, 1992, 340 (8825) :978-978

[7] LACK OF AN ASSOCIATION BETWEEN APOLIPOPROTEIN-E EPSILON-4 AND ALZHEIMERS-DISEASE IN ELDERLY NIGERIANS [J].

OSUNTOKUN, BO ;

SAHOTA, A ;

OGUNNIYI, AO ;

GUREJE, O ;

BAIYEWU, O ;

ADEYINKA, A ;

OLUWOLE, SO ;

KOMOLAFE, O ;

HALL, KS ;

UNVERZAGT, FW ;

HUI, SL ;

YANG, M ;

HENDRIE, HC .

ANNALS OF NEUROLOGY, 1995, 38 (03) :463-465

[8]

OTSUKA T, 1988, JPN J PSYCHIAT NEUR, V42, P223

[9] LACK OF ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET ALZHEIMERS-DISEASE AMONG FINNISH CENTENARIANS [J].

SOBEL, E ;

LOUHIJA, J ;

SULKAVA, R ;

DAVANIPOUR, Z ;

KONTULA, K ;

MIETTINEN, H ;

TIKKANEN, M ;

KAINULAINEN, K ;

TILVIS, R .

NEUROLOGY, 1995, 45 (05) :903-907

[10] THE APOLIPOPROTEIN-E EPSILON-2 ALLELE IS ASSOCIATED WITH AN INCREASED RISK OF EARLY-ONSET ALZHEIMERS-DISEASE AND A REDUCED SURVIVAL [J].

VANDUIJN, CM ;

DEKNIJFF, P ;

WEHNERT, A ;

DEVOECHT, J ;

BRONZOVA, JB ;

HAVEKES, LM ;

HOFMAN, A ;

VAN BROECKHOVEN, C .

ANNALS OF NEUROLOGY, 1995, 37 (05) :605-610

← 1 2 →