Structure of human translin at 2.2 Å resolution

被引：30

作者：

Sugiura, I

Sasaki, C

Hasegawa, T

Kohno, T

Sugio, S

Moriyama, H

Kasai, M

Matsuzaki, T

机构：

[1] ZowGene, Aoba Ku, Yokohama, Kanagawa 2278502, Japan

[2] Mitsubishi Chem Corp, Aoba Ku, Yokohama, Kanagawa 2278502, Japan

[3] Mitsubishi Kagaku Inst Life Sci, Machida, Tokyo 1948511, Japan

[4] RIKEN, Harima Inst, SPring8, Mikazuki, Hyogo 6795148, Japan

[5] Natl Inst Infect Dis, Dept Immunol, Shinjuku Ku, Tokyo 162, Japan

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2004年 / 60卷

关键词：

D O I：

10.1107/S0907444904002549

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of human translin at 2.2 Angstrom resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2 the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.

引用

页码：674 / 679

页数：6

共 20 条

[1] Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX [J].