Synthesis and folding preferences of γ-amino acid oligopeptides:: stereochemical control in the formation of a reverse turn and a helix

被引：94

作者：

Hanessian, S ^{[1
]}

Luo, XH ^{[1
]}

Schaum, R ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(99)00860-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of alpha-cinnamyl gamma-amino acids and the corresponding oligopeptides is described. Detailed 1D and 2D NMR. studies in pyridine-d(5) show that the (alpha R)-cinnamyl gamma-amino acid tetrapeptide adopts a reverse turn structure, while the (alpha S)-cinnamyl gamma-amino acid tetrapeptide adopts a right-handed helical structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4925 / 4929

页数：5

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