An octameric carbopeptoid; Secondary structure in octameric and tetrameric 5-aminomethyl-tetrahydrofuran-2-carboxylates

被引：78

作者：

Claridge, TDW

Long, DD

Hungerford, NL

Aplin, RT

Smith, MD

Marquess, DG

Fleet, GWJ

机构：

[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[3] Adv Med Inc, San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(99)00111-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of an octameric furanose carbopeptoid, readily purified by chromatography in ethyl acetate:hexane (2:1), is reported. Extensive NMR studies suggest that two tetrameric 5-aminomethyltetrahydrofuran-2-carboxylate are prone to adopt solution conformations reminiscent of a repeating beta-turn, a third tetramer and the corresponding octamer may tend towards a left-handed alpha-helix. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2199 / 2202

页数：4

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