Absence of secondary structure in a carbopeptoid tetramer of a trans-5-aminomethyl-tetrahydrofuran-2-carboxylate

被引:41
作者
Smith, MD
Long, DD
Martín, A
Marquess, DG
Claridge, TDW
Fleet, GWJ
机构
[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
[3] Adv Med Inc, San Francisco, CA 94080 USA
关键词
D O I
10.1016/S0040-4039(99)00109-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Whereas trimers and tetramers of beta-C-D-arabinofuranosyl carbohydrate amino acids adopt well defined conformations based around a repealing beta-turn like structure, stabilised by (i, i-2) inter-residue hydrogen bonds, there is no indication of any secondary structure in the tetramer of the epimeric alpha-C-D-arabinoluranosyl carbohydrate amino acid, where the C-2 and C-5 substituents of the tetrahydrofuran ring are Irans to each other. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2191 / 2194
页数:4
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