From sequencamers to foldamers?: Tetrameric furanose carbopeptoids from cis- and trans-5-aminomethyl-tetrahydrofuran-2-carboxylates

被引:61
作者
Long, DD
Hungerford, NL
Smith, MD
Brittain, DEA
Marquess, DG
Claridge, TDW
Fleet, GWJ
机构
[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
[3] Adv Med Inc, S San Francisco, CA 94080 USA
关键词
D O I
10.1016/S0040-4039(99)00110-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of three stereoisomeric cis- and trans-5-azidomelhyl-tetrahydrofuran-2-carboxylates in which a ketal-protected cis-diol unit is present is described. The monomers undergo efficient oligomerisation to tetrameric carbopeptoids in which the diol protection facilitates ready purification by chromatography which augurs well for the formation of homogeneous higher polymers. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2195 / 2198
页数:4
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