Extracellular modulation of the Hedgehog, Wnt and TGF-β signalling pathways during embryonic development

被引：30

作者：

Capdevila, J ^{[1
]}

Belmonte, JCI ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(99)80065-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Localized embryonic expression of members of the Hedgehog, Wnt and TGF-beta families of secreted factors has been shown to organize pattern and provide positional information in many developing systems. Recently, several extracellular factors have been described that act either as facilitators or inhibitors of the activities of those secreted proteins. The variety of molecular strategies involved in the extracellular modulation of signalling activities in the embryo underscores the importance of maintaining a tight spatial and temporal control of the activities of organizing centers during development.

引用

页码：427 / 433

页数：7

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