Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors

被引：35

作者：

Ganesh, V. ^{[1
]}

Bodewits, Karin ^{[1
]}

Bartholdson, S. Josefin ^{[1
]}

Natale, Daniela ^{[1
]}

Campopiano, Dominic J. ^{[1
]}

Mareque-Rivas, Juan C. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 02期

关键词：

anion receptors; dinuclear complexes; lipopolysaccharides; molecular recognition; sensors; HYDROGEN-BONDING INTERACTIONS; SELF-ASSEMBLED MONOLAYERS; ANION RECOGNITION; BURKHOLDERIA-CENOCEPACIA; IMPEDANCE SPECTROSCOPY; ANTIMICROBIAL PEPTIDES; COORDINATION-COMPLEXES; SELECTIVE RECOGNITION; AQUEOUS-SOLUTION; IN-VIVO;

D O I：

10.1002/anie.200804168

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Nature inspired: A synthetic receptor (see picture) that exploits two zinc(II) ions and four convergent amino hydrogen bonding groups binds lipopolysaccharides (LPSs) almost as strongly as the LPS binding protein. This feature is exploited to electrochemically distinguish LPS from other pathogens in water and in complex biological mixtures. Zn pink, N blue, P orange, O red. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：356 / 360

页数：5

共 61 条

[1]

[Anonymous], 1997, SUPRAMOLECULAR CHEM

[2]

AOKI S, 2002, REV MOL BIOTECHNOL, V90, P129

[3]

Beer P.D., 2001, ANGEW CHEM, V113, P502

[4]

Beer PD, 2001, ANGEW CHEM INT EDIT, V40, P486, DOI 10.1002/1521-3773(20010202)40:3<486::AID-ANIE486>3.0.CO

[5]

2-P

[6] Innate immune sensing and its roots: the story of endotoxin [J].

Beutler, B ;

Rietschel, ET .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (02) :169-176

[7] Macrocyclic anion receptors based on directed hydrogen bonding interactions [J].

Choi, KH ;

Hamilton, AD .

COORDINATION CHEMISTRY REVIEWS, 2003, 240 (1-2) :101-110

[8] ANALYSIS OF THE BINDING OF POLYMYXIN-B TO ENDOTOXIC LIPID-A AND CORE GLYCOLIPID USING A FLUORESCENT DISPLACEMENT PROBE [J].

DAVID, SA ;

BALASUBRAMANIAN, KA ;

MATHAN, VI ;

BALARAM, P .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1165 (02) :147-152

[9] Anion binding and transport by steroid-based receptors [J].

Davis, Anthony P. .

COORDINATION CHEMISTRY REVIEWS, 2006, 250 (23-24) :2939-2951

[10] Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics [J].

DiVittorio, Kristy M. ;

Leevy, W. Matthew ;

O'Neil, Edward J. ;

Johnson, James R. ;

Vakulenko, Sergei ;

Morris, Joshua D. ;

Rosek, Kristine D. ;

Serazin, Nathan ;

Hilkert, Sarah ;

Hurley, Scott ;

Marquez, Manuel ;

Smith, Bradley D. .

CHEMBIOCHEM, 2008, 9 (02) :286-293

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