Protein kinase C and phospholipase C: Bilayer interactions and regulation

Protein kinase C and phospholipase C are interfacially active modular enzymes that contain multiple membrane-binding domains. During the past two years, 3D structures and functional data have been reported for the key domains: pleckstrin homology, protein kinase C homology-l and -2, and the phospholipase C catalytic domain. Roles for membrane bilayer structure and lipid microdomains have become clearly defined. interdependent ligand binding to different protein domains has shown how the domains work together to coordinate regulation.