Molecular basis of osteoarthritis: biomechanical aspects

被引:82
作者
Kerin, A
Patwari, P
Kuettner, K
Cole, A
Grodzinsky, A
机构
[1] MIT, Ctr Biomed Engn, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[3] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Sch Med, Dept Biochem, Chicago, IL 60612 USA
关键词
biomechanics; osteoarthritis; mechanical loading; age; glycation; biosynthesis;
D O I
10.1007/s00018-002-8402-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The unique biomechanical properties of healthy cartilage ensure that articular cartilage is able to transmit force between the joints while maintaining almost friction-free limb movement. In osteoarthritis, the biomechanical properties are compromised, but we still do not understood whether this precedes the onset of the disease or is a result of it. This review focuses on the physical changes to cartilage with age, disease, and mechanical loading, with specific reference to the increased collagen cross-linking that occurs with age (nonenzymatic glycation), and the response of chondrocytes to physiological and pathological loads. In addition, the biomechanical properties and matrix biosynthesis of cartilage from various joint surfaces of the knee and ankle are compared to elucidate reasons why the ankle is less affected by progressive osteoarthritis than the knee.
引用
收藏
页码:27 / 35
页数:9
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