Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy

被引：333

作者：

Ozlem, Suriye ^{[3
]}

Akkaya, Engin U. ^{[1
,2
]}

机构：

[1] Bilkent Univ, Dept Chem, TR-06800 Ankara, Turkey

[2] Bilkent Univ, UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey

[3] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 01期

关键词：

DISTYRYL-BORADIAZAINDACENES; HALF-SUBTRACTOR; BODIPY DYES; ELEMENTS; EFFICIENT; CHEMISTRY; GATE;

D O I：

10.1021/ja808389t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple derivative of a welt-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule.

引用

页码：48 / +

页数：3

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