Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

被引：26

作者：

Gustafsson, Tomas ^{[1
]}

Sorensen, Henrik ^{[1
]}

Ponten, Fritiof ^{[1
]}

机构：

[1] AstraZeneca R&D, Med Chem, SE-43183 Molndal, Sweden

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 05期

关键词：

ORGANIC-SYNTHESIS;

D O I：

10.1021/op200340c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Early scale-up work of a promising reflux inhibitor AZD6906 is described. Two steps of an earlier route were adapted to be performed in continuous flow to avoid issues related to batch procedures, resulting in a robust method with reduced cost of goods and improved product quality. Toxic and reactive reagents and starting materials could be handled in a flow regime, thereby allowing safer and more convenient reaction optimization and production.

引用

页码：925 / 929

页数：5

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