Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

被引：822

作者：

Hartman, Ryan L. ^{[1
]}

McMullen, Jonathan P. ^{[1
]}

Jensen, Klavs F. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期

关键词：

continuous flow; flow chemistry; microfluidics; microreactors; synthetic chemistry; IODATE REACTION SYSTEM; MICROMIXING EFFICIENCY; HIGH-PRESSURE; MICROREACTION TECHNOLOGY; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; SEGMENTED FLOW; PROCESS INTENSIFICATION; MICROFLUIDIC SYNTHESIS; REACTION OPTIMIZATION;

D O I：

10.1002/anie.201004637

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scalesa - from the laboratory to full production. This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory. Flow or batch? The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scalesa - from the laboratory to full production. This Review discusses the relative merits of batch and microflow reactors for performing synthetic chemistry in the laboratory. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7502 / 7519

页数：18

共 195 条

[1] Mechanisms of mixing and creation of structure in laminar stirred tanks [J].