The Washington Heights-Inwood Genetic Study of Essential Tremor: Methodologic issues in essential-tremor research

被引：232

作者：

Louis, ED

Ottman, R

Ford, B

Pullman, S

Martinez, M

Fahn, S

Hauser, WA

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY

[2] COLUMBIA UNIV,COLL PHYS & SURG,GERTRUDE H SERGIEVSKY CTR,NEW YORK,NY

[3] COLUMBIA UNIV,NEW YORK STATE PSYCHIAT INST,EPIDEMIOL BRAIN DISORDERS RES DEPT,NEW YORK,NY

来源：

NEUROEPIDEMIOLOGY | 1997年 / 16卷 / 03期

关键词：

essential tremor; genetics; epidemiology; family history; methodology;

D O I：

10.1159/000109681

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Essential tremor (ET) is the most. prevalent movement disorder. It. is unknown to what extent ET clusters within families, and the role of genetic susceptibility in the etiology of ET has not been adequately investigated at the population level. The problem is largely methodological, with few well-designed studies, The Washington Heights-Inwood Genetic Study of ET, begun in 1995, is designed to investigate the genetics of ET using a methodology that has not been applied to ET research to date, Part of the design includes a new set of clinical and electrophysiological diagnostic criteria for ET; the present paper describes this novel study design.

引用

页码：124 / 133

页数：10