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Structural abnormalities of chromosome 2 in Benign thyroid tumors - Three new cases and review of the literature

被引：14
作者：
Bol, S
Belge, G
Thode, B
Bartnitzke, S
Bullerdiek, J
机构：
[1] Univ Bremen, Ctr Human Genet & Genet Counseling, D-28359 Bremen, Germany
[2] Cent Hosp, Dept Pathol, Bremen, Germany
来源：
CANCER GENETICS AND CYTOGENETICS | 1999年 / 114卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(99)00028-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Here we report our cytogenetic findings on three cases of nodular goiter, all showing structural clonal abnormalities of chromosome 2. In the first case, we found a t(2;3)(q21;q27 or, q28) in two nodules of the same patient. The second case revealed a t(2;20;3)(p21;q11.2;p25), and the third case showed a t(1;2)(p22;p13). When the data from the literature and the present cases are summarized, the results suggest the existence of at least three breakpoint clusters of chromosome 2 in benign thyroid tumors or hyperplasias. (C) Elsevier Science Inc., 1999. All rights reserved.
引用
收藏
页码：75 / 77
页数：3
相关论文
共 14 条
[1]   NUMERICAL ABERRATIONS, INCLUDING TRISOMY-22 AS THE SOLE ANOMALY, ARE RECURRENT IN FOLLICULAR THYROID ADENOMAS [J].
ANTONINI, P ;
LEVY, N ;
CAILLOU, B ;
VENUAT, AM ;
SCHLUMBERGER, M ;
PARMENTIER, C ;
BERNHEIM, A .
GENES CHROMOSOMES & CANCER, 1993, 8 (01) :63-66
[2]  
BELGE G, 1994, HUM GENET, V94, P198
[3]   Cytogenetic investigations of 340 thyroid hyperplasias and adenomas revealing correlations between cytogenetic findings and histology [J].
Belge, G ;
Rogue, L ;
Soares, J ;
Bruckmann, S ;
Thode, B ;
Fonseca, E ;
Clode, A ;
Bartnitzke, S ;
Castedo, S ;
Bullerdiek, J .
CANCER GENETICS AND CYTOGENETICS, 1998, 101 (01) :42-48
[4]   ABERRATIONS OF CHROMOSOME-19 - DO THEY CHARACTERIZE A SUBTYPE OF BENIGN THYROID ADENOMAS [J].
BELGE, G ;
THODE, B ;
BULLERDIEK, J ;
BARTNITZKE, S .
CANCER GENETICS AND CYTOGENETICS, 1992, 60 (01) :23-26
[5]  
Belge G, 1996, GENE CHROMOSOME CANC, V16, P149
[6]  
BONDESON L, 1989, CANCER, V64, P680, DOI 10.1002/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO
[7]  
2-I
[8]   From amplification to gene in thyroid cancer: A high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization [J].
Chen, XN ;
Knauf, JA ;
Gonsky, R ;
Wang, M ;
Lai, EH ;
Chissoe, S ;
Fagin, JA ;
Korenberg, JR .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (02) :625-637
[9]   INVOLVEMENT OF 19Q13 IN FOLLICULAR THYROID ADENOMA [J].
DALCIN, P ;
SNEYERS, W ;
ALY, MS ;
SEGERS, A ;
OSTIJN, F ;
VANDAMME, B ;
VANDENBERGHE, H .
CANCER GENETICS AND CYTOGENETICS, 1992, 60 (01) :99-101
[10]  
MITELMAN F, 1995, GUIDELINES CANC CYTO
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