Synthesis and reactivity of a transition metal-carbonyl imidoester designed for the selective and covalent labelling of biological macromolecules.

被引：14

作者：

Blanalt, S ^{[1
]}

Salmain, M ^{[1
]}

Malezieux, B ^{[1
]}

Jaouen, G ^{[1
]}

机构：

[1] ECOLE NORMALE SUPER CHIM PARIS,CNRS,LAB CHIM ORGANOMET,F-75231 PARIS,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 36期

关键词：

D O I：

10.1016/0040-4039(96)01416-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first transition metal-carbonyl water-soluble imidoester has been prepared in several steps and characterised by classical spectroscopic methods. It is aimed at the selective conjugation of amine-containing biomolecules such as proteins in aqueous medium,leading to conjugates that retain their net charge. A preliminary reactivity study with bovine serum albumin (BSA) is reported. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：6561 / 6564

页数：4

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