GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics

被引：163

作者：

Fujita, Morihisa ^{[1
]}

Kinoshita, Taroh

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2012年 / 1821卷 / 08期

关键词：

Endoplasmic reticulum; Glycosylphosphatidylinositol; Golgi apparatus; Lipid raft; Sorting; Trafficking; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; CLATHRIN-INDEPENDENT ENDOCYTOSIS; YEAST SACCHAROMYCES-CEREVISIAE; POLARIZED EPITHELIAL-CELLS; EARLY SECRETORY PATHWAY; CANINE KIDNEY-CELLS; ENDOPLASMIC-RETICULUM; GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHOR; TRYPANOSOMA-BRUCEI; GOLGI-APPARATUS;

D O I：

10.1016/j.bbalip.2012.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational modification in eukaryotes. GPI is synthesized and transferred to proteins in the endoplasmic reticulum. GPI-anchored proteins are then transported from the endoplasmic reticulum to the plasma membrane through the Golgi apparatus. GPI-anchor functions as a sorting signal for transport of GPI-anchored proteins in the secretory and endocytic pathways. After GPI attachment to proteins, the structure of the GPI-anchor is remodeled, which regulates the trafficking and localization of GPI-anchored proteins. Recently, genes required for GPI remodeling were identified in yeast and mammalian cells. Here, we describe the structural remodeling and function of GPI-anchors, and discuss how GPI-anchors regulate protein sorting, trafficking, and dynamics. This article is part of a Special Issue entitled Lipids and Vesicular Transport. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1050 / 1058

页数：9

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