Expression of zTlxA, a Hox11-like gene, in early differentiating embryonic neurons and cranial sensory ganglia of the zebrafish embryo

被引:23
作者
Andermann, P [1 ]
Weinberg, ES [1 ]
机构
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
关键词
Tlx-1; Tlx-3; Hox11; homeodomain; trigeminal; statoacoustic; vagal; lateral line; Rohon-Beard cells; semicircular canals;
D O I
10.1002/dvdy.1239
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
We have isolated a cDNA encoding a member of the Tlx/Hox11 family of homeodomain factors from the zebrafish, most closely related to the vertebrate Tlx-1/Hox11 and Tlx-3/Hox11L2 proteins. The gene is expressed in a set of early differentiating neurons that project to a common tract, the lateral longitudinal fascicle. We show that the gene is specifically expressed in spinal cord Rohon Beard neurons, in nucleus of the posterior commissure neurons of the midbrain, in a set of hindbrain neurons that include RoL3 reticulospinal interneurons, and in the trigeminal, statoacoustic, anterior lateral line, glossopharyngeal, and vagal cranial sensory ganglia. Timing of expression of the gene in these neurons correlates with the phase of axonal outgrowth and target innervation. Expression of the gene is also observed in several non-neural tissues, including the pharyngeal arches, budding gill filaments, outgrowing semicircular protrusions in the otic vesicle, and in the pectoral fin buds. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:595 / 610
页数:16
相关论文
共 56 条
[1]   THE EXPRESSION PATTERN OF 2 ZEBRAFISH ACHAETE-SCUTE HOMOLOG (ASH) GENES IS ALTERED IN THE EMBRYONIC BRAIN OF THE CYCLOPS MUTANT [J].
ALLENDE, ML ;
WEINBERG, ES .
DEVELOPMENTAL BIOLOGY, 1994, 166 (02) :509-530
[2]  
Appel B, 1995, DEVELOPMENT, V121, P4117
[3]   IDENTIFICATION OF SPINAL NEURONS IN THE EMBRYONIC AND LARVAL ZEBRAFISH [J].
BERNHARDT, RR ;
CHITNIS, AB ;
LINDAMER, L ;
KUWADA, JY .
JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 302 (03) :603-616
[4]   A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube [J].
Briscoe, J ;
Pierani, A ;
Jessell, TM ;
Ericson, J .
CELL, 2000, 101 (04) :435-445
[5]  
Butler A.B., 1996, COMP VERTEBRATE NEUR
[6]  
CHITNIS AB, 1990, J NEUROSCI, V10, P1892
[7]   ELIMINATION OF A BRAIN TRACT INCREASES ERRORS IN PATHFINDING BY FOLLOWER GROWTH CONES IN THE ZEBRAFISH EMBRYO [J].
CHITNIS, AB ;
KUWADA, JY .
NEURON, 1991, 7 (02) :277-285
[8]  
CLARKE JDW, 1993, DEVELOPMENT, V118, P151
[9]   A DROSOPHILA-MELANOGASTER HOMOLOG OF THE T-CELL ONCOGENE HOX11 LOCALIZES TO A CLUSTER OF HOMEOBOX GENES [J].
DEAR, TN ;
RABBITTS, TH .
GENE, 1994, 141 (02) :225-229
[10]   THE HOX11 GENE ENCODES A DNA-BINDING NUCLEAR TRANSCRIPTION FACTOR BELONGING TO A DISTINCT FAMILY OF HOMEOBOX GENES [J].
DEAR, TN ;
SANCHEZGARCIA, I ;
RABBITTS, TH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4431-4435