Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers

被引：17

作者：

Yamadera, H ^{[1
]}

Suzuki, H ^{[1
]}

Nakamura, S ^{[1
]}

Endo, S ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138603, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1999年 / 53卷 / 02期

关键词：

blood concentration; body core temperature; healthy volunteer; slow wave sleep; trazodone;

D O I：

10.1046/j.1440-1819.1999.00531.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Polysomnography. blood concentration and core body temperature recordings were performed on 12 healthy volunteers with administration of trazodone and placebo, Trazodone increased slow wave sleep (SWS), and decreased the average, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with amplitude (the difference between the highest and lowest temperature) and %SWS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.

引用

页码：189 / 191

页数：3

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