Complex cocktails: the evolutionary novelty of venoms

被引：674

作者：

Casewell, Nicholas R. ^{[1
,2
]}

Wuester, Wolfgang ^{[1
]}

Vonk, Freek J. ^{[3
]}

Harrison, Robert A. ^{[2
]}

Fry, Bryan G. ^{[4
]}

机构：

[1] Bangor Univ, Sch Biol Sci, Mol Ecol & Evolut Grp, Bangor LL57 2UW, Gwynedd, Wales

[2] Univ Liverpool, Liverpool Sch Trop Med, Alistair Reid Venom Res Unit, Liverpool L3 5QA, Merseyside, England

[3] Nat Biodivers Ctr, NL-2333 CR Leiden, Netherlands

[4] Univ Queensland, Sch Biol Sci, Venom Evolut Lab, St Lucia, Qld 4072, Australia

来源：

TRENDS IN ECOLOGY & EVOLUTION | 2013年 / 28卷 / 04期

基金：

英国惠康基金; 澳大利亚研究理事会; 英国自然环境研究理事会;

关键词：

venom; evolution; selection; convergence; gene duplication; antivenom; drug discovery; PREDATORY MARINE GASTROPOD; SPIDER CUPIENNIUS-SALEI; SENSING ION CHANNELS; ACCELERATED EVOLUTION; MOLECULAR EVOLUTION; MULTIGENE FAMILIES; ADAPTIVE EVOLUTION; GENE DUPLICATIONS; DNA IMMUNIZATION; RAPID EVOLUTION;

D O I：

10.1016/j.tree.2012.10.020

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Venoms have evolved on numerous occasions throughout the animal kingdom. These 'biochemical weapon systems' typically function to facilitate, or protect the producing animal from, predation. Most venomous animals remain unstudied despite venoms providing model systems for investigating predator-prey interactions, molecular evolution, functional convergence, and novel targets for pharmaceutical discovery. Through advances in 'omic' technologies, venom composition data have recently become available for several venomous lineages, revealing considerable complexity in the processes responsible for generating the genetic and functional diversity observed in many venoms. Here, we review these recent advances and highlight the ecological and evolutionary novelty of venom systems.

引用

页码：219 / 229

页数：11

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