Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

被引：48

作者：

Bergers, E

Bot, JCJ

van der Valk, P

Castelijns, JA

Lycklama, GJ

Kamphorst, W

Polman, CH

Blezer, ELA

Nicolay, K

Ravid, R

Barkhof, F

机构：

[1] VU Med Ctr, Dept Radiol, Amsterdam, Netherlands

[2] VU Med Ctr, Dept Pathol, Amsterdam, Netherlands

[3] VU Med Ctr, Dept Neurol, Amsterdam, Netherlands

[4] Univ Utrecht, Image Sci Inst, Utrecht, Netherlands

[5] Netherlands Brain Bank, Amsterdam, Netherlands

来源：

ANNALS OF NEUROLOGY | 2002年 / 51卷 / 05期

关键词：

D O I：

10.1002/ana.10170

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, I case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and I had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

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页码：652 / 656

页数：5

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