The first asymmetric synthesis of (2S)- and (2R)-amino-3,3-dimethoxypropanoic acid

被引：10

作者：

DeMong, DE ^{[1
]}

Williams, RM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 13期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(02)00269-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (alpha-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2355 / 2357

页数：3

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