Crystal structure of the macrophage migration inhibitory factor from rat liver

被引：176

作者：

Suzuki, M

Sugimoto, H

Nakagawa, A

Tanaka, I

Nishihira, J

Sakai, M

机构：

[1] HOKKAIDO UNIV,GRAD SCH SCI,DIV BIOL SCI,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,SCH MED,CENT RES INST,SAPPORO,HOKKAIDO 060,JAPAN

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 03期

关键词：

D O I：

10.1038/nsb0396-259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 M(r)) is presented at 2.2 Angstrom resolution, Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices., The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer, Unexpected similarities were detected between MIF and two kinds of isomerase.

引用

收藏

页码：259 / 266

页数：8

相关论文

共 43 条

[1] STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA [J].

ABRAHAMS, JP ;

LESLIE, AGW ;

LUTTER, R ;

WALKER, JE .

NATURE, 1994, 370 (6491) :621-628

[2] IN VITRO STUDIES ON HOMOGRAFT SENSITIVITY [J].

ALASKARI, S ;

DAVID, JR ;

LAWRENCE, HS ;

THOMAS, L .

NATURE, 1965, 205 (4974) :916-&

[3]

[Anonymous], ACTA CRYSTALLOGR D

[4] CRYSTAL-STRUCTURE OF INTERLEUKIN-8 - SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY [J].

BALDWIN, ET ;

WEBER, IT ;

STCHARLES, R ;

XUAN, JC ;

APPELLA, E ;

YAMADA, M ;

MATSUSHIMA, K ;

EDWARDS, BFP ;

CLORE, GM ;

GRONENBORN, AM ;

WLODAWER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :502-506

[5] MIF IS A PITUITARY-DERIVED CYTOKINE THAT POTENTIATES LETHAL ENDOTOXEMIA [J].

BERNHAGEN, J ;

CALANDRA, T ;

MITCHELL, RA ;

MARTIN, SB ;

TRACEY, KJ ;

VOELTER, W ;

MANOGUE, KR ;

CERAMI, A ;

BUCALA, R .

NATURE, 1993, 365 (6448) :756-759

[6] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[7] THE FOREIGN ANTIGEN-BINDING SITE AND T-CELL RECOGNITION REGIONS OF CLASS-I HISTOCOMPATIBILITY ANTIGENS [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :512-518

[8] HUMAN MIGRATION-INHIBITORY FACTOR - PURIFICATION AND IMMUNOCHEMICAL CHARACTERIZATION [J].

BLOCK, LH ;

JAKSCHE, H ;

BAMBERGER, S ;

RUHENSTROTHBAUER, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (02) :541-553

[9] MIF PROTEINS ARE THETA-CLASS GLUTATHIONE-S-TRANSFERASE HOMOLOGS [J].

BLOCKI, FA ;

ELLIS, LBM ;

WACKETT, LP .

PROTEIN SCIENCE, 1993, 2 (12) :2095-2102

[10] MECHANISM OF A REACTION IN VITRO ASSOCIATED WITH DELAYED-TYPE HYPERSENSITIVITY [J].

BLOOM, BR ;

BENNETT, B .

SCIENCE, 1966, 153 (3731) :80-&

← 1 2 3 4 5 →