Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery

被引：53

作者：

Amolins, M. W. ^{[1
]}

Blagg, B. S. J. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 02期

关键词：

Hsp90; inhibitors; cancer; neurodegenerative diseases; natural products; HEAT-SHOCK-PROTEIN; N-TERMINAL DOMAIN; IMPORTANT BIOLOGIC ACTIVITIES; ESCHERICHIA-COLI HSP90; MOLECULAR CHAPERONE; GELDANAMYCIN DERIVATIVES; CRYSTAL-STRUCTURE; ATP-BINDING; DNA GYRASE; ANTITUMOR-ACTIVITY;

D O I：

10.2174/138955709787316056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.

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页码：140 / 152

页数：13

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