Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings

被引：550

作者：

Meintjes, Graeme ^{[18
,20
,21
]}

Lawn, Stephen D. ^{[19
,22
]}

Scano, Fabio ^{[17
]}

Maartens, Gary

French, Martyn A. ^{[15
,16
]}

Worodria, William ^{[14
]}

Elliott, Julian H. ^{[13
]}

Murdoch, David ^{[11
,12
]}

Wilkinson, Robert J. ^{[9
,10
,20
,21
]}

Seyler, Catherine ^{[8
]}

John, Laurence ^{[7
]}

van der Loeff, Maarten Schim ^{[6
]}

Reiss, Peter ^{[6
]}

Lynen, Lut ^{[5
]}

Janoff, Edward N. ^{[3
,4
]}

Gilks, Charles ^{[2
]}

Colebunders, Robert ^{[1
,5
]}

机构：

[1] Univ Antwerp, Fac Med, B-2020 Antwerp, Belgium

[2] WHO, HIV Dept, CH-1211 Geneva, Switzerland

[3] Univ Colorado, Colorado Ctr AIDS Res, Denver, CO 80202 USA

[4] Denver Vet Affairs, Med Ctr, Hlth Sci Ctr, Denver, CO 80202 USA

[5] Inst Trop Med, B-2000 Antwerp, Belgium

[6] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[7] Chelsea & Westminster Hosp, London, England

[8] Univ Bordeaux 2, ISPED, F-33076 Bordeaux, France

[9] Univ London Imperial Coll Sci Technol & Med, Div Med, Wellcome Trust Ctr Res Clin Trop Med, London SW7 2AZ, England

[10] Natl Inst Med Res, London NW7 1AA, England

[11] Duke Univ, Med Ctr, Durham, NC 27706 USA

[12] Univ N Carolina, Chapel Hill, NC USA

[13] Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia

[14] Makerere Univ, Infect Dis Inst, Kampala, Uganda

[15] Univ Western Australia, Dept Clin Immunol, Royal Perth Hosp, Perth, WA 6009, Australia

[16] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA 6009, Australia

[17] WHO, HTM STBTHD, CH-1211 Geneva, Switzerland

[18] Univ Cape Town, Div Clin Pharmacol, Dept Med, ZA-7925 Cape Town, South Africa

[19] London Sch Hyg & Trop Med, Clin Res Unit, Dept Infect & Trop Dis, London WC1, England

[20] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[21] Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa

[22] Univ Cape Town, Desmond Tutu HIV Ctr, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

来源：

LANCET INFECTIOUS DISEASES | 2008年 / 8卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1473-3099(08)70184-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.

引用

页码：516 / 523

页数：8

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